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Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

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Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
3.4K

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Characterizing morphological alterations in blood related disorders through Atomic Force Microscopy.

Rohini Rakshak1, Shweta Bhatt1, Sushant Sharma1

  • 1Department of Bioscience and Bioengineering, Indian Institute of Technology, Bombay, India.

Nanotheranostics
|April 5, 2024
PubMed
Summary

Atomic Force Microscopy (AFM) reveals cellular changes in blood disorders like cancer and diabetes. This technique enhances understanding of disease progression and offers new clinical insights.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Medical Diagnostics

Background:

  • Atomic Force Microscopy (AFM) provides high-resolution topographical imaging of materials and biological surfaces.
  • AFM is increasingly utilized to analyze cellular morphology and biochemical properties of tissues and cells.
  • Understanding cellular alterations is crucial for diagnosing and managing diseases.

Purpose of the Study:

  • To review the application of AFM in analyzing blood-related disorders.
  • To highlight how AFM can detect morphological and surface characteristic changes in blood cells caused by various diseases.
  • To compare AFM findings in diseased blood cells with normal cells.

Main Methods:

  • Utilizing Atomic Force Microscopy (AFM) for high-resolution imaging of blood cells.
  • Comparing topographical, size, and shape characteristics of blood cells from patients with specific conditions to those of healthy individuals.
  • Analyzing alterations induced by cancer, diabetes, anemia, and pathogen infections.

Main Results:

  • AFM can discern subtle changes in blood cell morphology, size, and surface texture associated with diseases.
  • Detailed comparisons reveal distinct AFM signatures for conditions like cancer, diabetes, anemia, and infections.
  • The study demonstrates AFM's capability to identify disease-specific cellular alterations.

Conclusions:

  • AFM serves as a powerful tool for the in-depth analysis of blood-related pathologies.
  • This technique bridges the gap between traditional microscopy and advanced disease analysis.
  • AFM offers valuable perspectives for both research and clinical applications in hematology.