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Published on: August 28, 2018
The relationship between the systemic immune inflammatory index and computerized tomography guided coronary lesion
Uğur Aksu1, Cem Korucu1, Ramazan Anıl Ekşi1
1Faculty of Medicine, Department of Cardiology, Afyonkarahisar Health Sciences University, Afyon, Turkey.
Insights
In diabetic patients, elevated systemic immune inflammatory index (SII) indicates increased inflammation and is linked to coronary atherosclerosis severity. Lower HDL levels and lesion severity predict higher SII, suggesting further investigation for these patients.
Area of Science:
- Cardiology
- Diabetology
- Immunology
Background:
- Cardiovascular events are prevalent in diabetic patients.
- Elevated inflammatory markers in diabetics correlate with adverse outcomes.
- The systemic immune inflammatory index (SII) is a sensitive indicator of inflammatory response.
Purpose of the Study:
- To investigate the relationship between SII and coronary atherosclerosis severity in diabetic patients.
- To assess the utility of SII as a marker for inflammation in diabetes-related cardiovascular disease.
Main Methods:
- A cohort of 210 diabetic patients undergoing coronary computed tomography was analyzed.
- Patients were stratified based on median SII values.
- Predictors of elevated SII were identified using univariate and regression analyses.
Main Results:
- Lesion severity and lower HDL levels were identified as independent predictors of high SII.
- Univariate analysis showed associations between SII and HDL, triglyceride, lesion severity, and coronary artery restenosis (CAR).
Conclusions:
- Inflammation significantly contributes to the development of coronary atherosclerosis in diabetic individuals.
- Diabetic patients with elevated SII warrant further evaluation for significant coronary atherosclerosis.
Purpose:
The incidence of cardiovascular events is high in diabetic patients. In diabetic patients, the levels of inflammatory parameters in the circulation are increased, which is associated with poor outcome. In this study, we investigated the relationship between the systemic immune inflammatory index (SII), which is a sensitive indicator of the inflammatory response, and the severity of coronary atherosclerosis in diabetic patients.
Materials And Methods:
Diabetic patients who underwent coronary computed tomography for chest pain were included in the study. The patients were divided into two groups according to their median systemic immune inflammatory index values, and the predictors of SII elevation were investigated.
Results:
A total 210 patients were included in the study. The mean age of the patients was 52.6 ± 9.3 and 44.3% were male. In univariate analysis, HDL, triglyceride, lesion severity, and CAR were associated with high SII. In the regression analysis, lesion severity and lower HDL levels were determined as predictor of high SII.
Conclusion:
Inflammation plays an important role in the development of coronary atherosclerosis. Diabetic patients with elevated SII levels may require further investigation for significant atherosclerosis.
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