Related Experiment Video
Updated: Jun 29, 2025
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
The CXCR4 might be a potential biomarker for esophageal squamous cell carcinoma: A meta-analysis
Pei Chen1, Yu-Ling Zhang1, Xiao-Lei Zhang1
1Department of Basic Medical, Jiangsu College of Nursing, Huai'an, China.
Objective:
To evaluate the relationship between CXCL12/CXCR4 and the progress, prognosis of esophageal squamous cell carcinoma (ESCC), providing evidence for potential early diagnosis, clinical treatment, prognosis evaluation, and therapeutic target of ESCC.
Methods:
Databases of PubMed, the Cochrane Library, Embase, and Web of Science were searched for the relationship between CXCL12/CXCR4 and clinicopathological characteristics and survival time of ESCC. Stata16.0 software was used to conduct meta-analysis.
Results:
A total of 10 studies involving 1216 cases of patients with ESCC were included in our study. The results indicated that high-level expression of CXCR4 was significantly correlated with tumor differentiation [OR = 0.69, 95% confidence interval (CI): (0.50, 0.97)], tumor infiltration [OR = 0.39, 95% CI: (0.25, 0.61)], lymph node metastasis [OR = 0.36, 95% CI: (0.21, 0.61)], clinical stage [OR = 0.33, 95% CI: (0.24, 0.45)] of ESCC. The expression of CXCR4 was also significantly correlated with OS [HR = 2.00, 95% CI: (1.63, 2.45)] and disease-free survival [HR = 1.76, 95% CI: (1.44, 2.15)] in patients of ESCC after surgical resection. No significant relationship was observed between the expression of CXCL12 and the clinicopathological characteristics of ESCC.
Conclusion:
CXCR4 might be a potential biomarker for the progress and prognosis evaluation, and therapeutic target for ESCC.
