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Perineural invasion in cervical cancer: A multicenter retrospective study
Xiaolin Chen1, Hui Duan1, Hongwei Zhao2
1Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Summary
Perineural invasion (PNI) diagnosis in cervical cancer lacks accuracy. PNI is an independent risk factor for survival and can guide postoperative adjuvant treatment decisions.
Area of Science:
- Oncology
- Pathology
- Gynecologic Oncology
Background:
- Perineural invasion (PNI) is a prognostic factor in various cancers.
- Accurate diagnosis of PNI in cervical cancer is crucial for treatment planning.
Purpose of the Study:
- To evaluate the diagnostic accuracy of PNI in cervical cancer.
- To analyze the impact of PNI on prognosis and adjuvant treatment decisions.
Main Methods:
- Retrospective pathological review of 1208 cervical cancer cases from 2004-2016.
- Analysis of PNI diagnostic accuracy, risk factors, and survival outcomes.
Main Results:
- PNI diagnosis exhibited high false negative (33.33%) and false positive (5.35%) rates.
- Adenocarcinoma, deep stromal invasion, lymphovascular space invasion (LVSI), and margin involvement were independent PNI risk factors.
- PNI significantly worsened 5-year overall survival (OS) and disease-free survival (DFS), independent of treatment.
Conclusions:
- PNI diagnosis in cervical cancer is not fully accurate.
- PNI is an independent prognostic factor for cervical cancer survival.
- PNI can potentially serve as a high-risk factor to guide postoperative adjuvant therapy.
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