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Updated: Jun 29, 2025
04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
6.6K
Cross Talk between MicroRNAs and Dengue Virus.
Nur Omar Macha1, Thamil Vaani Komarasamy1, Sarahani Harun2
1Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia.
The American Journal of Tropical Medicine and Hygiene
|April 5, 2024
Summary
Dengue fever (DF) is a global threat spread by mosquitoes. Specific microRNAs (miRNAs) show promise in regulating dengue virus (DENV) replication and host immune responses, offering new therapeutic targets.
Area of Science:
- Virology
- Immunology
- Molecular Biology
Background:
- Dengue fever (DF) is a significant tropical infectious disease caused by dengue virus (DENV) and transmitted by Aedes mosquitoes.
- Current DF vaccines have limitations, necessitating novel therapeutic strategies.
- MicroRNAs (miRNAs) are implicated in host responses to DENV infection and viral replication.
Purpose of the Study:
- To review the role of specific miRNAs in regulating DENV replication.
- To explore the impact of these miRNAs on the host's initial immune response to DENV.
Main Methods:
- Literature review focusing on the involvement of miRNAs in DENV infection.
- Analysis of studies investigating the function of specific miRNAs (let-7c, 133a, 30e, 146a) in DENV replication and immune response.
Main Results:
- Specific miRNAs, including let-7c, miR-133a, miR-30e, and miR-146a, are involved in modulating DENV replication.
- These miRNAs play a role in the host's immune response during DENV infection.
Conclusions:
- Targeting specific miRNAs presents a potential strategy for novel dengue therapies.
- Further research into miRNA-DENV interactions is crucial for developing effective treatments against dengue fever.
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