Polymorphisms in the CD6-ALCAM axis may modulate psoriasis risk and outcomes
Marta Wagner1, Maciej Sobczyński2, Andrzej Wiśniewski3
1Laboratory of Genetics and Epigenetics of Human Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Human Immunology
|April 5, 2024
Summary
Genetic variations in CD6 and ALCAM genes may influence psoriasis risk and severity. Specifically, the rs17824933G allele is linked to increased psoriasis risk in certain individuals, and gene polymorphisms affect disease outcomes.
Area of Science:
- Immunogenetics
- Dermatology
- Molecular Biology
Background:
- CD6 and its ligand ALCAM are crucial in T cell activation.
- T cell-mediated diseases, like psoriasis vulgaris (PsV), are potential targets for CD6-ALCAM research.
- Genetic polymorphisms in CD6 and ALCAM warrant investigation for their role in PsV.
Purpose of the Study:
- To investigate the association between CD6 and ALCAM gene polymorphisms and psoriasis susceptibility and severity.
- To explore the influence of these polymorphisms in conjunction with the HLA-C*06:02 risk factor.
- To assess the impact on the Psoriasis Area and Severity Index (PASI) scores.
Main Methods:
- Genotyping of CD6 (rs17824933, rs11230563, rs12360861) and ALCAM (rs6437585, rs11559013) polymorphisms using TaqMan SNP Genotyping Assays.
- Case-control study involving 273 psoriasis vulgaris patients and 256 healthy controls.
- Analysis of HLA-C*06:02 presence and its interaction with CD6/ALCAM polymorphisms and PASI scores.
Main Results:
- The rs17824933G allele of CD6 showed an association with increased psoriasis risk in HLA-C*06:02 positive individuals (OR=1.87, p=0.0350).
- A significant difference in average PASI scores was observed based on the number of minor alleles in CD6 and ALCAM polymorphic sites (F=6.159, p=0.0026).
- No significant association was found for other investigated polymorphisms with psoriasis risk or severity.
Conclusions:
- Polymorphisms in the CD6-ALCAM axis genes may play a role in modulating psoriasis susceptibility and clinical outcomes.
- The interplay between CD6, ALCAM, and HLA-C*06:02 warrants further investigation in psoriasis pathogenesis.
- These genetic factors could serve as potential biomarkers for disease risk and severity assessment.
Related Concept Videos
01:24T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
01:20The JAK-STAT Signaling Pathway
8.9K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.9K
01:33Pleiotropy
40.4K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
40.4K
01:22iPS Cell Differentiation
2.7K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.7K