Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Imaging Studies IV: Magnetic Resonance Imaging

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cancer detection in the European Randomised Study of Screening for Prostate Cancer (ERSPC).

BJU international·2026

Same author

Diabetes and Cancer-Specific Survival: A Nationwide Population-Based Cohort Study Across Multiple Cancer Sites.

Cancer reports (Hoboken, N.J.)·2026

Same author

Comparison of the Swedish and Finnish Centers in the European Randomized Study of Screening for Prostate Cancer (ERSPC).

European urology open science·2026

Same author

PI-RADS v2 and Adverse Prostate Cancer Outcomes: A Cross-cohort Replication Study Across Three Centers.

European urology oncology·2026

Same author

Association of Childhood Acute Leukemia With Autoimmune Diseases.

International journal of cancer·2026

Same author

Mortality From Amyotrophic Lateral Sclerosis in Finland 1987-2022.

European journal of neurology·2026

Search research articles

Related Experiment Video

Updated: May 18, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

Prostate Cancer Screening With PSA, Kallikrein Panel, and MRI: The ProScreen Randomized Trial.

Anssi Auvinen¹, Teuvo L J Tammela^2,3, Tuomas Mirtti^4,5,6,7,8

¹Tampere University, Unit of Health Sciences, Faculty of Social Sciences, Tampere, Finland.

|April 6, 2024

Summary

This summary is machine-generated.

A prostate cancer screening protocol including PSA testing, a 4-kallikrein panel, and MRI detected more high-grade cancers. This preliminary study suggests potential benefits for early prostate cancer detection in men aged 50-63.

More Related Videos

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 18, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

Published on: June 6, 2025

Area of Science:

Urology
Oncology
Public Health

Background:

Prostate-specific antigen (PSA) screening can reduce prostate cancer mortality.
However, it often identifies clinically insignificant cancers, leading to overtreatment.
Newer screening protocols aim to improve the detection of clinically significant prostate cancer.

Purpose of the Study:

To evaluate the detection rates of low-grade and high-grade prostate cancer using a multi-modal screening protocol.
To compare cancer detection rates between men invited to screening and a control group.

Main Methods:

The ProScreen trial randomized over 60,000 men aged 50-63 to either an invitation for screening or no invitation.
The screening protocol involved PSA testing, a 4-kallikrein panel, and MRI for eligible men.
Cancer incidence was compared between the invited and control groups.

Main Results:

The screening invitation group had a cumulative incidence of 0.26% for low-grade and 1.13% for high-grade prostate cancer.
The control group had a cumulative incidence of 0.14% for low-grade and 0.62% for high-grade prostate cancer.
The risk difference was 0.11% for low-grade and 0.51% for high-grade cancer in favor of the invited group.

Conclusions:

A single round of this multi-modal screening detected 1 additional high-grade cancer per 196 men and 1 low-grade cancer per 909 men compared to no screening.
These are preliminary findings from an ongoing trial, and interpretation should await primary mortality outcome results.
The study highlights the potential of combined PSA, kallikrein panel, and MRI for detecting significant prostate cancer.