Two-dimensional metal-organic framework nanozyme-mediated portable paper-based analytical device for dichlorophen...

Area of Science:

• Environmental Science
• Materials Science
• Analytical Chemistry

Background:

• Metal-organic frameworks (MOFs) nanozymes show promise for environmental pollutant detection.
• Challenges include poor dispersibility and reduced activity of traditional MOF nanozymes.
• Paper-based analytical devices (PADs) offer portable detection solutions.

Purpose of the Study:

• To develop a colorimetric PAD for visual detection of dichlorophen (Dcp).
• To overcome limitations of existing MOF nanozymes in dispersibility and activity.
• To utilize the inhibitory effect of Dcp on MOF nanozyme activity for sensing.

Main Methods:

• Synthesis of a 2D Copper-based MOF nanozyme (2D-CTF) with iron doping.
• Utilized the peroxidase-like (POD-like) activity of 2D-CTF to catalyze TMB oxidation.
• Investigated the inhibitory effect of Dcp on 2D-CTF POD-like activity.

Main Results:

• Synthesized 2D-CTF exhibits excellent dispersibility and high POD-like activity under neutral conditions.
• Dcp uniquely inhibits the POD-like activity of 2D-CTF by occupying Fe-N4 active sites.
• Developed colorimetric PADs for visual and portable detection of Dcp.

Conclusions:

• The 2D-CTF based colorimetric PAD provides an efficient method for Dcp detection.
• This approach offers a new avenue for developing sensors for phenolic toxic substances.
• The study addresses limitations in MOF nanozyme application for environmental monitoring.