Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Refining current risk stratification guidelines for pregnant women with Fontan circulation: lessons from PROFAT registry.

European journal of preventive cardiology·2025
Same author

Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.

Journal of magnetic resonance imaging : JMRI·2025
Same author

Pre-procedural virtual reality education reduces anxiety in patients undergoing atrial septal closure - Results from a randomized trial.

International journal of cardiology. Congenital heart disease·2024
Same author

Improved Risk Prediction Using a Refined European Guidelines Instrument in Pulmonary Arterial Hypertension Related to Congenital Heart Disease.

The American journal of cardiology·2024
Same author

Clinical Course of TGA After Arterial Switch Operation in the Current Era.

JACC. Advances·2024
Same author

Improved Outcomes After Pulmonary Valve Replacement in Repaired Tetralogy of Fallot.

Journal of the American College of Cardiology·2023

Related Experiment Video

Updated: Jul 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K

Decreased clinical performance in TGA-ASO patients after RVOT interventions; a multicenter European collaboration.

Leo J Engele1, Víctor González-Fernández2, Barbara J M Mulder1

  • 1CAHAL, Center for Congenital Heart Disease Amsterdam-Leiden, location Amsterdam University Medical Center, Amsterdam, the Netherlands.

International Journal of Cardiology
|April 7, 2024
PubMed
Summary

Transposition of the great arteries patients after arterial switch repair show reduced exercise capacity. Interventions for right ventricular outflow tract obstruction further decrease performance compared to those without interventions.

Keywords:
Arterial switch operationPeak-VO2Re-interventionRight ventricular outflow tract obstructionTransposition of the great arteries

More Related Videos

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

11.7K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.6K

Related Experiment Videos

Last Updated: Jul 1, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.5K
Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
08:50

Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement

Published on: March 26, 2018

11.7K
Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
08:12

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels

Published on: May 26, 2023

1.6K

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Congenital Heart Disease

Background:

  • Right ventricular outflow tract (RVOT) obstruction is a frequent complication in patients with transposition of the great arteries following an arterial switch operation (TGA-ASO).
  • RVOT obstruction often necessitates repeat interventions to restore adequate blood flow.

Purpose of the Study:

  • To evaluate cardiopulmonary exercise capacity and right ventricular (RV) function in TGA-ASO patients.
  • To compare outcomes based on the type of RVOT intervention received.

Main Methods:

  • Stratified TGA-ASO patients (≥16 years) by RVOT intervention type.
  • Assessed predicted peak oxygen uptake (peak VO2), tricuspid annular plane systolic excursion (TAPSE), tricuspid lateral annular systolic velocity (TV S'), RV-arterial coupling, and N-terminal proBNP (NT-proBNP).

Main Results:

  • Patients without prior RVOT intervention (76%) had significantly higher predicted peak VO2 (78.0 ± 17.4%) compared to those with single or multiple RVOT interventions.
  • RV-arterial coupling was significantly lower in patients with prior catheter-based and/or surgical RVOT interventions compared to those without any intervention (p=0.029).

Conclusions:

  • TGA-ASO patients exhibit decreased exercise capacity post-arterial switch repair.
  • Patients undergoing catheter or surgical RVOT interventions demonstrate significantly poorer outcomes compared to those without such interventions.