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Tirzepatide-Induced Ketoacidosis in Non-Diabetic Patients
Pathan Mohamad Rafe Iqbal1, Ossama Sajeh Maadarani2, Zouheir Ibrahim Bitar2
1Internal Medicine Department, New Ahamdi Hospital, Kuwait Oil Company, Fahahil, Kuwait.
Background:
Tirzepatide is a novel glucagon-like peptide 1/glucose-dependent insulinotropic peptide (GLP-1/GIP) receptor agonist. It was recently approved for diabetes control and weight reduction in non-diabetic patients.
Case Description:
We report the first case of ketoacidosis after the use of tirzepatide in an obese non-diabetic patient, secondary to the possibility of starvation ketoacidosis and insulin resistance.
Conclusion:
The dual-acting GLP-1 and GIP receptor agonists, tirzepatide, can induce ketoacidosis in obese non-diabetic patients.
Learning Points:
The dual-acting GLP-1 and GIP receptor agonists can cause ketoacidosis in obese non-diabetic patients.Ketoacidosis induced by tirzepatide is serious, and physicians should be aware of this complication and be alert to early symptoms, check serum and urine ketone levels, and stop medication.
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