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Panitumumab-Induced Periorbital Dermatitis: A Case Report
Napapat Pongbangpho1, Kumutnart Chanprapaph1, Wimolsiri Iamsumang1
1Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clinical, Cosmetic and Investigational Dermatology
|April 8, 2024
Summary
Panitumumab, an epidermal growth factor receptor (EGFR) inhibitor, can cause rare periorbital dermatitis. This case highlights the need to consider this specific skin reaction in patients undergoing EGFR inhibitor therapy.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Panitumumab is an EGFR inhibitor used for advanced colorectal cancer.
- Common side effects include skin conditions like acneiform dermatitis.
- Ocular and periocular toxicities are less common but reported.
Observation:
- An 81-year-old Thai female with advanced sigmoid colon cancer developed periorbital dermatitis.
- This occurred after treatment with panitumumab plus modified FOLFOX6.
- The reaction recurred but responded to topical therapy.
Findings:
- Panitumumab-induced periorbital dermatitis is exceptionally rare.
- This case highlights a potential periocular cutaneous reaction to EGFR inhibitors.
- Literature review confirms the rarity of this specific side effect.
Implications:
- Periorbital dermatitis should be considered a potential side effect of panitumumab.
- Early recognition and prompt treatment are crucial for patient management.
- Awareness among clinicians is important for managing EGFR inhibitor toxicities.
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