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D-Penicillamine-Induced Stevens-Johnson Syndrome in a Patient with Gold Cyanide Intoxication: A Case Report
Tanaporn Anuntrangsee1, Kumutnart Chanprapaph1, Wimolsiri Iamsumang1
1Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Clinical, Cosmetic and Investigational Dermatology
|November 4, 2024
Summary
D-penicillamine, a chelating agent, can rarely cause Stevens-Johnson syndrome (SJS), a severe skin reaction. Prompt discontinuation is crucial for patients with SJS following D-penicillamine treatment.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- D-penicillamine is a primary treatment for Wilson's disease and heavy metal intoxication.
- It is known to cause various systemic and cutaneous side effects.
Observation:
- A case of a 23-year-old Thai female with gold intoxication is presented.
- She developed Stevens-Johnson syndrome (SJS) after D-penicillamine treatment.
Findings:
- D-penicillamine-induced Stevens-Johnson syndrome (SJS) is exceptionally rare.
- This case highlights a potentially fatal cutaneous adverse drug reaction.
Implications:
- D-penicillamine should be considered a potential cause of SJS.
- Early recognition and discontinuation of D-penicillamine are vital in managing SJS.
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