Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stochastic free energy transduction.

H V Westerhoff, Y Chen

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Time-dependent regulation of yeast glycolysis upon nitrogen starvation depends on cell history.

    IET systems biology·2010
    Same author

    Approaches to biosimulation of cellular processes.

    Journal of biological physics·2009
    Same author

    Control, responses and modularity of cellular regulatory networks: a control analysis perspective.

    IET systems biology·2008
    Same author

    BDI-modelling of complex intracellular dynamics.

    Journal of theoretical biology·2007
    Same author

    Systems biology: new paradigms for cell biology and drug design.

    Ernst Schering Research Foundation workshop·2007
    Same author

    Summation theorems for flux and concentration control coefficients of dynamic systems.

    Systems biology·2006
    Same journal

    Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Tomographic imaging of superconducting order using particle-hole interference.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Analytical modeling for suction cup designs for skin-interfaced wearable devices.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Improving cell-free metabolism through direct integration of artificial respiratory chains.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    Theoretical models show that limited numbers of protons per coupling unit lead to unique behaviors in free-energy systems. These findings explain experimental observations in proton-linked energy transduction.

    Area of Science:

    • Biophysics
    • Biochemical Thermodynamics

    Background:

    • Proton-linked free-energy transduction is crucial for cellular energy.
    • Existing models often assume bulk proton gradients, which may not fully explain experimental data.

    Purpose of the Study:

    • To investigate the theoretical properties of free-energy coupling systems with limited intermediates.
    • To reconcile theoretical predictions with experimental observations in proton-linked systems.

    Main Methods:

    • Theoretical modeling of free-energy coupling systems.
    • Analysis of reaction kinetics and thermodynamics under limited intermediate conditions.

    Main Results:

    • Systems with few intermediates exhibit non-conventional rate laws.

    Related Experiment Videos

  • Output reaction rates show complex dependencies on intermediate concentration.
  • Apparent violations of the second law of thermodynamics can occur.

    • Conclusions:

    • Limiting the number of protons per coupling unit explains observed phenomena in proton-linked energy transduction.
    • Chemiosmotic coupling theory can account for experimental data when considering small numbers of protons.
    • These findings suggest a more direct coupling mechanism than previously assumed in some systems.