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Utilizing bioprinting to engineer spatially organized tissues from the bottom-up
Yichen Zhan1,2, Wenbin Jiang1,2, Zhirong Liu3,4
1Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Stem Cell Research & Therapy
|April 8, 2024
Summary
Bottom-up tissue engineering constructs functional organ substitutes using precise building blocks. Bioprinting is a key technology for fabricating and assembling these components, advancing regenerative medicine.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Organ substitute demand drives tissue engineering advancements.
- Creating functional tissues and organs remains a significant challenge.
- Bottom-up tissue engineering offers a promising approach for complex tissue construction.
Purpose of the Study:
- To review fabrication and assembly techniques for building blocks in bottom-up tissue engineering.
- To elaborate on the mechanisms and applications of bioprinting within this strategy.
- To provide insights into future trends in bottom-up tissue engineering.
Main Methods:
- Review of techniques for building block fabrication and assembly.
- Detailed explanation of bioprinting mechanisms and applications.
- Analysis of current research in bottom-up tissue engineering.
Main Results:
- Bioprinting is a versatile and automated technique for precise tissue engineering.
- Bioprinting enables the construction of multi-material tissues with high accuracy.
- Various techniques exist for both building block creation and their subsequent assembly.
Conclusions:
- Bottom-up tissue engineering, particularly with bioprinting, shows great potential for creating complex functional tissues.
- Continued research and development in fabrication and assembly techniques are crucial.
- This review serves as a reference for researchers in the field of bottom-up tissue engineering.
