Molecular Iodine as a Catalyst for Alkene Difluorination
Tsugio Kitamura1, Juzo Oyamada1, Masahiro Higashi2
1Department of Chemistry and Applied Chemistry, Saga University, Saga 840-8502, Japan.
Abstract:
The difluorination reaction of alkenes catalyzed by molecular iodine was revealed for the first time. This difluorination reaction affords a simple and practical experimental method and can be applied to many aliphatic and aromatic alkenes bearing synthetically useful functional groups, such as ester, amide, hydroxy, and aryl groups. Preliminary mechanistic studies of this alkene difluorination suggest the existence of two catalytic cycles: the IF-driven cycle and the catalytic cycle by the IF adduct.
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