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Published on: November 9, 2017
A case series of post-infectious chikungunya myeloradiculoneuropathy
Suresh Selvam1, Padma Youron2, Harpreet Singh1
1Division of Clinical Infectious Diseases, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
Abstract:
Chikungunya fever is an arboviral illness caused by chikungunya virus (CHIKV) and transmitted by the bite of Aedes aegypti and Aedes albopictus. It is an RNA virus belonging to the genus Alphavirus and family Togaviridae. We present a case series of three patients with chikungunya illness developing para/post-infectious myeloradiculoneuropathy.These patients developed neurological symptoms in the form of bilateral lower limb weakness with sensory and bowel involvement after the recovery from the initial acute episode of chikungunya fever. Clinical examination findings suggested myeloradiculoneuropathy with normal Magnetic Resonance Imaging of the Spine, with the nerve conduction study showing sensorimotor axonal polyneuropathy. All the patients were treated with 1 g of methylprednisolone once a day for five days, and case 2 was given intravenous immunoglobulin also. In the follow-up, cases 1 and 2 showed complete recovery without recurrence, and case 3 did not show improvement at one month.
Insights
Chikungunya virus (CHIKV) infection can lead to rare neurological complications like myeloradiculoneuropathy. Early treatment with methylprednisolone showed promising recovery in two of three patients with this chikungunya complication.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Chikungunya fever is a mosquito-borne viral illness caused by the chikungunya virus (CHIKV).
- Neurological complications, though rare, can occur following CHIKV infection.
- Para/post-infectious myeloradiculoneuropathy is a potential neurological sequela of chikungunya.
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