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Multiple coronary heart diseases are risk factors for mental health disorders: A mendelian randomization study

Tianwei Meng1, Zhiping Liu2, Jiawen Liu1

  • 1Heilongjiang University of Chinese Medicine, Harbin, 150006, China.

Heart & Lung : the Journal of Critical Care
|April 9, 2024
PubMed

Insights

This study used Mendelian randomization to find that certain heart diseases, like coronary artery disease, may cause mental health disorders. Mental health disorders were not found to cause heart disease.

Area of Science:

  • Cardiovascular Epidemiology
  • Psychiatric Genetics
  • Biostatistics

Background:

  • Observational studies suggest links between Coronary Heart Disease (CHD) and Mental Health Disorders (MHD).
  • The causal direction of these associations remains unclear.

Purpose of the Study:

  • To investigate the causal relationships between eight types of CHD and six types of MHD.
  • Utilize Mendelian randomization (MR) analysis for robust causal inference.

Main Methods:

  • Employed multiple MR methods: IVW, MR-Egger, weighted median, and mode techniques.
  • Assessed heterogeneity and pleiotropy using IVW and MR-Egger.
  • Validated results with leave-one-out sensitivity analysis.

Main Results:

  • Coronary Artery Disease and Myocardial Infarction causally increase the risk of Major Depressive Disorder and Mania.
  • Heart Failure causally increases the risk for Bipolar Disorder and Schizophrenia.
  • Atrial Fibrillation and Ischemic Heart Diseases link to Generalized Anxiety Disorder and Mania.

Conclusions:

  • Specific Coronary Heart Disease types may be causal risk factors for certain Mental Health Disorders.
  • Suggests integrating psychological assessments into CHD patient management.
Abstract

Keywords:
Causal relationshipsGeneticsMajor depressive disorderSchizophrenia

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