Related Experiment Video
Updated: Jun 28, 2025
10:10
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
8.7K
Rebuilding and rebooting immunity with stem cells.
Laura N Stankiewicz1, Fabio M V Rossi1, Peter W Zandstra2
1School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Cell Stem Cell
|April 9, 2024
Summary
Immune regeneration therapies aim to combat age-related diseases by restoring immune function. This review highlights critical safety and design questions for advancing these promising regenerative medicine strategies.
Area of Science:
- Immunology
- Regenerative Medicine
- Biotechnology
Background:
- Modern medicine increases lifespan, making age-related diseases more prevalent.
- The immune system plays a crucial role in aging and age-related conditions.
- Immune regeneration therapies offer potential solutions for age-related diseases.
Purpose of the Study:
- To identify key unanswered questions regarding the safety and feasibility of immune regeneration therapies.
- To outline critical design parameters for developing effective immune regeneration technologies.
Main Methods:
- Literature review and expert consultation on current immune regeneration strategies.
- Analysis of safety, efficacy, and design considerations for therapeutic interventions.
Main Results:
- Several critical questions regarding the safety and feasibility of immune regeneration therapies remain.
- Key design parameters include timing, host immune interaction, and patient characterization.
Conclusions:
- Addressing safety and design challenges is crucial for the clinical translation of immune regeneration therapies.
- Further research is needed to optimize these strategies for treating age-related diseases.
Keywords:
agingbioengineeringbiomaterialsimmunityimmunotherapyregenerative medicinestem cell transplantthymus involutionMore Related Videos
Related Concept Videos
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:23Cells of the Adaptive Immune Response
983
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
983
01:23Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
01:23Tissue Renewal without Stem Cells
1.7K
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
1.7K
01:40Cell-mediated Immune Responses
68.2K
Overview
68.2K
01:17Stem Cell Culture
5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K