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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
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Rebuilding and rebooting immunity with stem cells

Laura N Stankiewicz1, Fabio M V Rossi1, Peter W Zandstra2

  • 1School of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.

Cell Stem Cell
|April 9, 2024
PubMed

Advances in modern medicine have enabled a rapid increase in lifespan and, consequently, have highlighted the immune system as a key driver of age-related disease. Immune regeneration therapies present exciting strategies to address age-related diseases by rebooting the host's primary lymphoid tissues or rebuilding the immune system directly via biomaterials or artificial tissue. Here, we identify important, unanswered questions regarding the safety and feasibility of these therapies. Further, we identify key design parameters that should be primary considerations guiding technology design, including timing of application, interaction with the host immune system, and functional characterization of the target patient population.

Keywords:
agingbioengineeringbiomaterialsimmunityimmunotherapyregenerative medicinestem cell transplantthymus involution

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