Related Experiment Video

Updated: Jun 28, 2025

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

13.7K

Efficacy and Safety of Single-Dose Pregabalin in Preoperative Pediatric Sedation

Wafiya Mahdy1, Khaled Saad2, Eman F Gad2

  • 1Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

Journal of Pharmacy & Bioallied Sciences
|April 10, 2024
PubMed

Insights

A single oral dose of pregabalin effectively reduced preoperative anxiety and provided sedation in pediatric surgical patients. This anxiolytic and sedative effect was achieved without an increase in adverse events.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery
  • Pharmacology

Background:

  • Preoperative anxiety and sedation are critical considerations in pediatric surgery.
  • Effective anxiolytic and sedative agents are needed to improve patient outcomes.
  • Pregabalin is a medication with known anxiolytic properties.

Purpose of the Study:

  • To investigate the anxiolytic and sedative effects of a single oral dose of pregabalin (5 mg/kg) in pediatric patients undergoing elective surgery.
  • To assess the impact of pregabalin on bispectral index (BIS) responses.
  • To evaluate potential adverse effects of pregabalin in this population.

Main Methods:

  • Prospective randomized clinical trial involving 60 pediatric patients.
  • Random assignment to oral pregabalin (5 mg/kg) or placebo one hour before anesthesia induction.
  • Assessment of anxiety using Visual Analog Scale for Anxiety (VAS-A) and sedation using Ramsay Sedation Scale (RSS).

Main Results:

  • Pregabalin significantly reduced preoperative anxiety (lower VAS-A scores) compared to placebo.
  • Significantly higher sedation levels (RSS) were observed in the pregabalin group.
  • Lower bispectral index (BIS) responses were noted during intubation, skin incision, and recovery in the pregabalin group.

Conclusions:

  • A single preoperative dose of pregabalin effectively decreases anxiety in pediatric surgical patients.
  • Pregabalin achieves a state of sedation without a significant increase in adverse effects.
  • Pregabalin demonstrates potential as a safe and effective premedication in pediatric surgery.
Abstract

Keywords:
Anxietypediatric patientspregabalinsedative agent

More Related Videos

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.4K
Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement06:58

Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

Published on: June 25, 2016

19.1K

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
119
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
171
Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

Anxiolytic Drugs: Benzodiazepines and Buspirone

Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
721
Antiepileptic Drugs: Potassium Channel Activators01:20

Antiepileptic Drugs: Potassium Channel Activators

Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
176
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
430
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
355