Platelet-Rich Fibrin (PRF) and its Application in Dentistry: A Literature Review

Poulami Goswami1, Vivek Chaudhary2, Ashtha Arya3

  • 1Department of Oral Medicine and Radiology, Mithila Minority Dental College and Hospital, Darbhanga, Bihar, India.

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Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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