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Vitamin D Levels Assessment among the Neonates with and without Seizures: A Single Center Cross-Sectional Study
Nilamadhab Prusty1, Sai Y Peela2, Haifa Manaf3
1Department of ENT, FM Medical College, Balasore, Odisha, India.
Insights
Vitamin D levels in newborns with seizures were similar to healthy infants. However, all neonates studied had low vitamin D levels, suggesting a need for interventions to improve vitamin D status in this population.
Area of Science:
- Neonatal Medicine
- Endocrinology
- Neurology
Background:
- Vitamin D's impact on various health conditions, including neurological disorders, is a significant area of research.
- Vitamin D deficiency is notably more prevalent in individuals with epilepsy compared to the general population.
- Previous research indicates a potential link between vitamin D status and neurological conditions.
Purpose of the Study:
- To investigate vitamin D levels in newborns experiencing seizures.
- To compare vitamin D status between neonates with seizures and healthy controls.
- To assess the correlation between maternal and neonatal vitamin D levels.
Main Methods:
- A cross-sectional study was conducted at a tertiary care center with a neonatal intensive care unit (NICU).
- Participants included term and late preterm neonates with convulsions admitted to the NICU and healthy controls from the postnatal unit.
- Vitamin D levels were measured in both neonates and their mothers, with statistical significance set at P < 0.05.
Main Results:
- The study included 72 neonates, with 37 in the seizure group and 40 controls.
- Average maternal vitamin D levels were 15.11 ng/mL, and neonatal levels were 13.26 ± 5.12 ng/mL.
- No significant difference in vitamin D levels was observed between neonates with seizures and healthy controls (P = 0.212).
Conclusions:
- The study found no significant association between serum vitamin D levels and epileptic activity in neonates.
- All neonates in the study exhibited vitamin D levels below 20 ng/mL, indicating widespread deficiency.
- Interventions aimed at improving vitamin D levels in newborns are recommended.
Introduction:
The impact that vitamin D (vit D) has on a variety of medical conditions like diabetes, cardiovascular, oncological, and central nervous system disorders has been a topic of interest for many years now. It is well-known that vit D deficiency is substantially more common in epileptics than in healthy subjects. The current research was piloted to analyse the vit D levels of the blood in newborns with seizures, as well as mothers' vit D status included subjects.
Materials And Methods:
A cross-sectional examination was piloted at a tertiary care center, which had a neonatal intensive care unit (NICU). The subjects were neonates and their mothers. The levels of vit D were measured in term and late preterm newborns who had been brought to the NICU with convulsions. Term or late preterm infants who were healthy and hospitalized in the same hospital's postnatal unit as their mothers served as the controls for the study. Demographics, as well as the vit D levels of both the neonate and the mother, were estimated and compared and evaluated for any significance, keeping significance at less than 0.05.
Results:
Of the 72 neonates included, they were similarly distributed between the epileptic (37) and healthy subjects. (40) The mothersy subjects.cluded, they were sim D levels averaged 15.11 ded, they were similarly distributed b D levels of their newborns were 13.26 ± 5.12 ng/mL (P = 0.77). There was no significant variance between the healthy and epileptic neonates (P = 0.212).
Conclusion:
The current studyficant variance between the healthy and epileptic neonates (eptic with convulsions. Termserum vit D levels and epileptic activity in neonates. Nevertheless, the levels of the vitamin were < 20 ng/mL among all the neonates. Interventions to improve the vit D levels have to be implemented.
