SERS-based microdevices for use as in vitro diagnostic biosensors

Area of Science:

• Nanotechnology and Spectroscopy
• Biomedical Diagnostics
• Point-of-Care Testing

Background:

• Traditional in vitro diagnostics face limitations in sensitivity and multiplexing.
• Surface-enhanced Raman scattering (SERS) offers high sensitivity and multiplex detection capabilities.
• Developing SERS-based assay platforms for clinical samples is crucial for disease diagnosis.

Purpose of the Study:

• To review microdevices for SERS detection in point-of-care (POC) diagnostics.
• To present research on SERS-based bioassays for various diseases over the past 20 years.
• To discuss the future prospects of SERS bioassays integrated with POC systems and AI.

Main Methods:

• Review of microdevices: LFA strips, microfluidic chips, and microarray chips for SERS detection.
• Analysis of research findings on SERS bioassays for cancer, cardiovascular, and infectious diseases (last 20 years).
• Discussion on integrating SERS microdevices with portable Raman readers and AI for POC applications.

Main Results:

• SERS detection overcomes limitations of traditional diagnostic methods.
• Various microdevices (LFA, microfluidic, microarray chips) are suitable for SERS-based bioassays.
• SERS bioassays have shown promise in diagnosing cancer, cardiovascular diseases, and infectious diseases.

Conclusions:

• SERS-based bioassays, utilizing microdevices, are effective for sensitive and multiplexed disease detection.
• The integration of SERS microdevices with portable readers and AI holds significant potential for advanced POC diagnostics.
• Continued research and development in SERS microdevice technology will enhance disease diagnosis and management.