Host-Guest Stimuli-Responsive Click Chemistry.

Area of Science:

• Supramolecular Chemistry
• Organic Synthesis

Background:

• Traditional click chemistry offers irreversible molecular ligation but lacks reversibility.
• Limitations include side products, slow kinetics, and sensitivity to reaction conditions.
• Non-covalent click chemistry, using host-guest systems, provides a more efficient and controllable alternative.

Purpose of the Study:

• To review the implementation of molecular switches in non-covalent click chemistry.
• To introduce the concept of stimuli-responsive click chemistry.
• To highlight the potential for human-controlled molecular conjugation.

Main Methods:

• Discussion of host-guest self-assembled systems.
• Integration of molecular switches for external control.
• Analysis of thermodynamically regulated processes and extrinsic control mechanisms.

Main Results:

• Stimuli-responsive click chemistry enables reversible control over molecular binding states.
• Host-guest complexes facilitate stable yet labile non-covalent ligation.
• Demonstration of externally controlled molecular conjugation through selected examples.

Conclusions:

• Stimuli-responsive click chemistry mimics natural systems for controlled molecular assembly.
• This approach advances function-oriented chemical synthesis.
• Offers a powerful platform for developing human-controlled molecular conjugation strategies.