Related Experiment Video
Updated: Jul 12, 2026
08:26
Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
12.1K
Nanoparticle-assisted Targeting Delivery Technologies for Preventing Organ Rejection
Fanchao Meng1,2, Yang Fu3, Haiyang Xie2
1Jinan Microecological Biomedicine Shandong Laboratory, Jinan, Shandong Province, People's Republic of China.
Transplantation
|April 10, 2024
Summary
Nanodelivery systems offer a promising approach to improve organ transplant tolerance by precisely targeting rejection mechanisms. These advanced strategies aim for effective immunosuppression without harming the entire immune system, enhancing patient outcomes.
Area of Science:
- Biomaterials Science
- Immunology
- Transplantation Medicine
- Nanotechnology
Background:
- Organ transplantation is vital but challenged by post-transplant rejection.
- Current immunosuppressive drugs have limitations, impacting overall host immunity.
- Need for safer, more effective immune modulation strategies is critical.
Purpose of the Study:
- To review recent advances in nanodelivery systems for post-transplant rejection.
- To explore biomaterial-assisted formulations for targeted immunosuppression.
- To discuss precision delivery at organ- or immune cell-level.
Main Methods:
- Review of current literature on nanodrug delivery for transplantation.
- Analysis of biomaterial-assisted formulations and targeting technologies.
- Overview of transplant rejection mechanisms and existing therapies.
Main Results:
- Nanodelivery systems show potential to overcome limitations of conventional immunosuppressants.
- Targeted nanodrug delivery offers precision for organ or immune cell specificity.
- Biomaterial-assisted strategies can achieve therapeutic efficacy with reduced systemic toxicity.
Conclusions:
- Nanodelivery holds promise for achieving transplant tolerance with preserved host immunity.
- Targeted delivery technologies are advancing treatment for graft rejection.
- Biomaterial-assisted strategies represent a significant step toward clinical translation.
Related Concept Videos
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...