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Updated: Jun 28, 2025

Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
[Research progress in the relationship of hypoxia-inducible factor 1 with prostate diseases in hypoxic environment]
Ze-Chao Zhang1, Peng-Yu Mai1, Min Zhu1
1Department of Dermatology and Venereology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 530011, China .
Abstract:
The relationship between male prostate diseases and the hypoxic microenvironment has drawn increasing attention from the medical world. The role of hypoxia-inducible factor 1 (HIF-1), a typical factor for the hypoxic microenvironment, in prostate diseases is one of the hotspots in recent studies. HIF-1 plays an important role in different prostate diseases by participating in metabolic reprogramming, angiogenesis, tissue remodeling, immune regulation and other life activities. This review focuses on the action mechanisms of HIF-1 in prostatitis, prostatic hyperplasia and prostate cancer.
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