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In Situ Bioprinting: Process, Bioinks, and Applications.

Pooja Jain¹, Himanshu Kathuria², Seeram Ramakrishna³

¹Faculty of Dentistry, National University of Singapore, Singapore 119805, Singapore.

ACS Applied Bio Materials

|April 10, 2024

Summary

This summary is machine-generated.

In situ bioprinting offers personalized regenerative medicine by directly depositing biomaterials for patient-specific tissue fabrication. This review explores techniques, bioinks, and challenges for clinical translation.

Keywords:

3D bioprinting Bioinks Biomaterials In vivo bioprinting In-situ Printing Intraoperative bioprinting

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Area of Science:

Regenerative Medicine
Biomedical Engineering
Materials Science

Background:

Traditional tissue engineering faces limitations in scaffold fabrication and clinical accessibility.
In situ bioprinting emerges as a promising alternative for on-site, patient-specific tissue regeneration.

Purpose of the Study:

To review in situ bioprinting techniques, bioink materials, and their properties.
To discuss challenges and future trends for clinical translation of in situ bioprinting.

Main Methods:

Review of current literature on in situ bioprinting technologies.
Analysis of bioink compositions and critical material properties.
Discussion of application across various tissue types (skin, bone, cartilage, muscle).

Main Results:

In situ bioprinting enables precise, on-demand fabrication of complex tissue constructs.
Bioinks are crucial for cell viability and functional tissue development.
The technology aligns with precision medicine principles for personalized treatments.

Conclusions:

In situ bioprinting presents a significant advancement for personalized regenerative medicine.
Overcoming current challenges is key to accelerating clinical translation.
Future trends focus on optimizing bioinks and printing strategies for broader healthcare applications.