Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinguishing Th17 cells as a unique subset.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Aging-dependent change in Th17 and cytokine response in multiple sclerosis.

Journal of neuroinflammation·2025
Same author

Aging-dependent Change in Th17 and Cytokine Response in Multiple Sclerosis.

medRxiv : the preprint server for health sciences·2025
Same author

Changing behind the scenes.

The Journal of experimental medicine·2024
Same author

Serum cytokine profiles of adults with idiopathic inflammatory myopathies.

Clinical and experimental rheumatology·2024
Same author

Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.

Science signaling·2023

Related Experiment Video

Updated: Jun 28, 2025

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

10.9K

Gums make IL-23, no professionals needed.

Mandy J McGeachy1

  • 1Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA.

Immunity
|April 10, 2024
PubMed
Summary

Oral epithelial cells critically produce IL-23, driving inflammation in periodontitis. This finding links microbial imbalance to non-hematopoietic regulation of IL-17-driven inflammatory diseases.

Area of Science:

  • Immunology
  • Oral Biology
  • Microbiology

Background:

  • Interleukin-23 (IL-23) is a key cytokine that activates pathogenic T helper 17 (Th17) cells.
  • Th17-associated inflammation driven by IL-23 contributes to inflammatory diseases at various barrier surfaces.
  • Periodontitis is a chronic inflammatory condition affecting the tissues supporting the teeth, often linked to microbial dysbiosis.

Purpose of the Study:

  • To identify the critical cellular source of IL-23 in periodontitis.
  • To elucidate the link between microbial dysbiosis and the regulation of IL-17-associated inflammation in periodontitis.
  • To investigate the role of non-hematopoietic cells in the pathogenesis of periodontitis.

Main Methods:

  • Analysis of IL-23 production in human and mouse models of periodontitis.

More Related Videos

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.0K
Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
10:25

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

Published on: June 12, 2019

7.3K

Related Experiment Videos

Last Updated: Jun 28, 2025

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
05:07

Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network

Published on: February 16, 2016

10.9K
Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models
05:16

Author Spotlight: Enhancing Dental Pulp Research with Improved Mouse Models

Published on: October 27, 2023

1.0K
Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas
10:25

Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas

Published on: June 12, 2019

7.3K
  • Investigating the cellular origin of IL-23, focusing on oral epithelial cells.
  • Assessing the relationship between microbial dysbiosis and IL-23/IL-17 pathways.

    • Main Results:

    • Oral epithelial cells were identified as critical producers of IL-23 in both human and mouse periodontitis.
    • The study links microbial dysbiosis to the non-hematopoietic regulation of IL-17-associated inflammation.
    • This highlights a novel pathway in the pathogenesis of periodontitis.

    Conclusions:

    • Oral epithelial cells play a significant role in driving IL-17-mediated inflammation in periodontitis through IL-23 production.
    • The findings establish a connection between oral microbiota and the immune response in periodontitis.
    • Targeting IL-23 production by epithelial cells may offer a therapeutic strategy for periodontitis.