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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Related Experiment Video

Updated: Jun 14, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Mucoadhesive polymers: Design of S-protected thiolated cyclodextrin-based hydrogels.

Andrea Fürst1, Gergely Kali1, Aida Dizdarević1

  • 1Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.

International Journal of Pharmaceutics
|April 10, 2024
PubMed
Summary

Chemically crosslinked thiolated cyclodextrin hydrogels demonstrate enhanced mucoadhesion and sustained drug release. These novel hydrogels show improved mucosal residence time, making them promising for drug delivery applications.

Keywords:
CrosslinkingCyclodextrinsHydrogelsMucosal residence timeThiolated cyclodextrinsThiomers

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Cyclodextrins (CDs) are widely used in drug delivery.
  • Thiolated CDs offer enhanced properties compared to native CDs.
  • Hydrogels provide a versatile platform for drug encapsulation and release.

Purpose of the Study:

  • To design and synthesize chemically crosslinked thiolated cyclodextrin-based hydrogels.
  • To evaluate the mucoadhesive properties of these hydrogels.
  • To assess their potential for controlled drug release.

Main Methods:

  • Synthesis of S-protected thiolated β-cyclodextrin (β-CD-SH) using MESNA.
  • Crosslinking of β-CD-SH with citric acid to form hydrogels.
  • Characterization of hydrogels via rheology, mucoadhesion studies (mucosal residence time), and cytotoxicity assays (hemolysis, resazurin assay).
  • In vitro release studies using ritonavir as a model drug.

Main Results:

  • The synthesized S-protected β-CD-SH hydrogels exhibited significantly reduced hemolysis and minor cytotoxicity.
  • Rheological studies showed a substantial increase in viscosity for thiolated CD hydrogels compared to native CD hydrogels.
  • Mucosal residence time studies demonstrated a 16.6-fold and 2.4-fold lower removal from porcine intestinal and buccal mucosa, respectively, for thiolated CD hydrogels.
  • Sustained release of ritonavir was observed from the thiolated β-CD-based hydrogels.

Conclusions:

  • S-protected thiolated β-CD-based hydrogels possess superior mucoadhesive properties.
  • These hydrogels exhibit excellent drug release-controlling capabilities.
  • The developed hydrogels represent promising systems for effective mucosal drug delivery.