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Updated: Jun 28, 2025

Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Induced membrane technique using beta-tricalcium phosphate for reconstruction of clavicle bone defect after fracture
Kunihiko Arakawa1, Yoshinobu Watanabe1, Gen Sasaki1
1Department of Orthopaedic Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Abstract:
The induced membrane technique (IMT) is among the most innovative reconstructive methods for clavicle defects after fracture-related infection (FRI). Herein, we report a case in which a clavicle bone defect after FRI was reconstructed with an autogenous cancellous bone graft mixed with β-tricalcium phosphate (β-TCP) in the second stage of the IMT. A 62-year-old male patient with left clavicle fracture underwent open reduction and internal fixation. Refracture occurred immediately after the implant was removed. The patient was diagnosed with FRI after reopen reduction and internal fixation and was then referred to our hospital. The surgery was performed using the IMT. In the second stage of the IMT, the bone defect was filled with an autogenous cancellous bone mixed with wool-type β-TCP. At 8 months after surgery, the nonunion area had fused, and the patient had no restrictions in activities of daily living. The IMT with β-TCP can be a reconstructive method for bone defects after clavicular nonunion.

