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Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

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Event-related desynchronization and synchronization in multiple sclerosis.

Benjamin Bardel¹, Moussa A Chalah², Ruben Bensais-Rueda²

¹Univ Paris Est Créteil, Excitabilité Nerveuse et Thérapeutique (ENT), EA 4391, Créteil F-94010, France; Department of Clinical Neurophysiology, AP-HP, Henri Mondor University Hospital, DMU FIxIT, Creteil F-94010, France.

Multiple Sclerosis and Related Disorders

|April 11, 2024

Summary

This summary is machine-generated.

Patients with multiple sclerosis show altered motor control, with delayed brain activation and reduced post-movement responses detected via electroencephalography (EEG). These changes may involve compensatory mechanisms in deep brain structures.

Keywords:

Event-related desynchronization Event-related synchronization Motor function Multiple sclerosis Sensorimotor network

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A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

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Published on: December 26, 2015

Area of Science:

Neuroscience
Clinical Neurology
Biomedical Engineering

Background:

Motor preparation and execution are often impaired in patients with multiple sclerosis (pwMS).
Electroencephalography (EEG) can assess neural processes like event-related desynchronization (ERD) and event-related synchronization (ERS) during self-paced movements.

Purpose of the Study:

To compare ERD/ERS changes in pwMS with those in healthy controls (HC).

Main Methods:

Sixty-channel EEG was recorded from 13 pwMS and 10 HC during self-paced finger movements.
ERD and ERS parameters (latency, duration, amplitude) were analyzed in alpha and beta bands across five cortical regions.
Clinical and neuroimaging variables, including deep brain structure volumes and lesion load, were assessed.

Main Results:

Alterations in pwMS were primarily observed in the beta band, showing delayed ERD onset and shortened/increased amplitude.
Beta-ERD changes correlated with executive functions and caudate nucleus volume.
Beta-ERS changes included shorter duration, delayed onset, or reduced amplitude, linked to fatigue levels and thalamic volume.

Conclusions:

Multiple sclerosis is associated with altered motor preparation and execution, marked by delayed cortical activation (ERD) and impaired post-movement inhibition (ERS) in the beta band.
Potential compensatory mechanisms involving deep brain structures may underlie preserved clinical performance in some pwMS.