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Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Compounded Pain Formulations: What is the Evidence?

Scott Asbill1, Sarah M Sweitzer2, Shuler Spigener2

  • 1Department of Pharmaceutical and Administrative Sciences, Presbyterian College School of Pharmacy, Clinton, South Carolina. csasbill@presby.edu.

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Chronic pain affects many, increasing with aging and disease. Pharmacist-compounded topical pain gels offer alternatives, but their efficacy and permeation require further study.

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Area of Science:

  • Neurology
  • Pharmacology
  • Dermatology

Background:

  • Chronic pain syndromes are prevalent, costly neurological disorders exacerbated by aging, obesity, and diabetes.
  • Many chronic pain conditions are resistant to conventional pharmacotherapy and surgical interventions.
  • Pharmacist-compounded medications, particularly topical/transdermal analgesics, have seen a significant rise in use for pain management.

Approach:

  • This review examines the disease of chronic pain, its underlying mechanisms, and current treatment modalities.
  • It focuses on drugs commonly compounded into topical/transdermal formulations like gels and creams for pain relief.
  • The review discusses the limited understanding of permeation and efficacy of these topical compounds.

Key Points:

  • Topical/transdermal gels and creams are increasingly used for conditions like diabetic neuropathy, fibromyalgia, and arthritis.
  • Established systemic drug efficacy does not directly translate to topical formulation performance.
  • Further research is needed to understand the clinical effectiveness and drug permeation of these compounded topical analgesics.

Conclusions:

  • The increasing prevalence of chronic pain necessitates exploration of alternative treatments.
  • Pharmacist-compounded topical analgesics represent a growing area of pain management.
  • Investigating the permeation and efficacy of these topical formulations is crucial for optimizing patient care.