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Related Experiment Video

Updated: Jun 28, 2025

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices

Published on: September 20, 2019

Injectable Fluorescent Neural Interfaces for Cell-Specific Stimulating and Imaging.

Shumao Xu¹, Xiao Xiao¹, Farid Manshaii¹

¹Department of Bioengineering, University of California, Los Angeles, Los Angeles, California 90095, United States.

|April 12, 2024

Summary

This summary is machine-generated.

Injectable fluorescent neural interfaces minimize photothermal damage for safer, more accurate neuronal imaging. This advancement enhances brain-machine interfaces by improving safety and effectiveness.

Keywords:

calcium fluorescence imaging fluorescent neural interfaces genetically encoded indicators injectable bioelectronics

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Last Updated: Jun 28, 2025

In Vivo Intracerebral Stereotaxic Injections for Optogenetic Stimulation of Long-Range Inputs in Mouse Brain Slices

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Published on: September 20, 2019

Retrograde Fluorescent Labeling Allows for Targeted Extracellular Single-unit Recording from Identified Neurons In vivo

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Published on: June 26, 2013

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Published on: March 3, 2023

Area of Science:

Biomedical Engineering
Neuroscience
Bioelectronics

Background:

Traditional optogenetics carries risks of photothermal damage.
Accurate neuronal imaging is crucial for understanding brain function.

Purpose of the Study:

To introduce injectable fluorescent neural interfaces as a safer alternative to traditional optogenetics.
To enhance the accuracy and safety of neuronal imaging and recording.

Main Methods:

Utilizing injectable microelectronics for targeted electrical stimulation.
Integrating cell-specific genetically encoded calcium indicators with injectable bioelectronics.
Focusing on calcium fluorescence for imaging instead of stimulation.

Main Results:

Minimization of photothermal damage and conversion.
Improved accuracy in neuronal imaging and recording of individual neurons.
Enhanced safety, specificity, and effectiveness of neural imaging techniques.

Conclusions:

Injectable fluorescent neural interfaces offer a minimally invasive solution with improved usability and reliability.
This approach significantly reduces risks associated with photothermal effects.
Represents a major advancement for brain-machine interfaces and neuroscience research.