Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cadmium Exposure May Induce Potential Brain Tumour Initiation by Regulating SHH, GLI1, BMI1 and P53 in the SHH-GLI1 Cell Signalling Pathway.

Annals of neurosciences·2026
Same author

CD6 in Human Disease.

Cells·2025
Same author

The role of the adenylate kinase 5 gene in various diseases and cancer.

Journal of clinical and translational science·2024
Same author

Differential regulation of Shh-Gli1 cell signalling pathway on homeodomain transcription factors Nkx2.2 and Pax6 during the medulloblastoma genesis.

Molecular biology reports·2024
Same author

Homeodomain Transcription Factors Nkx2.2 and Pax6 as Novel Biomarkers for Meningioma Tumor Treatment.

Indian journal of clinical biochemistry : IJCB·2024
Same author

Glioblastoma Biology, Genetics and Possible Therapies.

Cells·2023

Related Experiment Video

Updated: Jun 28, 2025

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

8.3K

Mesenchymal-Stem-Cell-Based Therapy against Gliomas.

Sisa M Santillán-Guaján1, Mehdi H Shahi2, Javier S Castresana1

  • 1Department of Biochemistry and Genetics, University of Navarra School of Sciences, 31008 Pamplona, Spain.

Cells
|April 12, 2024
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for glioblastoma treatment by delivering therapies. Research explores enhancing MSC efficacy through gene delivery, oncolytic viruses, and advanced strategies like CAR-T cells and exosomes.

Keywords:
CAR-Texosomesglioblastomamesenchymal stem cellsnanoparticlestropism

More Related Videos

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells
10:28

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

8.3K
Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
09:26

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

Published on: July 29, 2011

16.7K

Related Experiment Videos

Last Updated: Jun 28, 2025

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
09:18

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds

Published on: July 16, 2018

8.3K
Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells
10:28

Flow Cytometry-based Drug Screening System for the Identification of Small Molecules That Promote Cellular Differentiation of Glioblastoma Stem Cells

Published on: January 10, 2018

8.3K
Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens
09:26

Method for Novel Anti-Cancer Drug Development using Tumor Explants of Surgical Specimens

Published on: July 29, 2011

16.7K

Area of Science:

  • Neuro-oncology
  • Stem Cell Therapy
  • Biomedical Engineering

Background:

  • Glioblastoma is an aggressive, lethal brain tumor with poor treatment outcomes.
  • Current treatments (surgery, radiotherapy, chemotherapy) are often inefficient against glioblastoma.
  • Mesenchymal stem cells (MSCs) are being investigated for glioblastoma cell therapy due to unique properties.

Purpose of the Study:

  • To explore the potential of mesenchymal stem cells (MSCs) in glioblastoma treatment.
  • To review strategies for enhancing MSC therapeutic efficacy against glioblastoma.
  • To discuss the dual antitumor and pro-tumor properties of MSCs in glioblastoma context.

Main Methods:

  • Review of literature on mesenchymal stem cells (MSCs) for glioblastoma therapy.
  • Analysis of MSCs' tumor tropism, immunomodulatory, and differentiation capabilities.
  • Exploration of therapeutic delivery systems including genes, oncolytic viruses, and miRNAs via MSCs.

Main Results:

  • MSCs exhibit potential for targeted glioblastoma therapy.
  • MSC efficacy can be modulated by their tissue origin, showing both anti- and pro-tumor effects.
  • Advanced strategies like CAR-T cells, nanoparticles, and exosomes can enhance MSC-mediated glioblastoma treatment.

Conclusions:

  • Mesenchymal stem cells (MSCs) offer a promising platform for novel glioblastoma therapies.
  • Further research is needed to optimize MSC-based strategies and overcome their dual properties.
  • Combining MSCs with gene therapy, virotherapy, and nanotechnology holds significant therapeutic potential.