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Published on: June 15, 2019
The Association of Serum Complement C1q with Coronary Artery Disease: A Systematic Review and Meta-Analysis
Insights
Serum complement C1q is elevated in patients with coronary artery disease (CAD). This meta-analysis found higher C1q levels in CAD patients compared to healthy individuals, suggesting a potential role in disease pathogenesis.
Area of Science:
- Cardiovascular Science
- Immunology
- Biochemistry
Background:
- Coronary artery disease (CAD) is a leading cause of mortality globally, with increasing incidence.
- Understanding CAD pathogenesis is crucial for patient health and effective management.
- Serum complement C1q (C1q) is implicated in inflammatory processes relevant to cardiovascular health.
Purpose of the Study:
- To conduct a meta-analysis investigating the association between serum C1q levels and the presence of CAD.
- To provide insights into the potential role of C1q in CAD diagnosis and treatment strategies.
Main Methods:
- A systematic literature search was performed in PubMed and Web of Science.
- Inclusion-exclusion criteria were applied by two independent researchers, with quality assessment using the Newcastle-Ottawa Scale (NOS).
- Statistical analysis was conducted using RevMan 5.3 software.
Main Results:
- Three high-quality studies (NOS score ≥6) involving 2065 participants (1249 CAD patients, 816 controls) were included.
- Meta-analysis revealed significantly higher serum C1q levels in CAD patients compared to healthy controls (P < .05).
- Subgroup analyses indicated that age, sex, sample size, diabetes status, and detection methods did not significantly affect heterogeneity; further data are needed for verification.
Conclusions:
- Elevated serum C1q levels are associated with coronary artery disease.
- The precise role and clinical implications of C1q in CAD require further investigation due to potential dual effects.
- This finding highlights C1q as a potential biomarker for CAD.
Background:
Coronary artery disease (CAD) is one of the leading causes of death in middle-aged and elderly people, and its incidence has been increasing in recent years. An in-depth understanding of the pathogenesis of CAD is important to ensure the health of CAD patients.
Objective:
To analyze the association of serum complement C1q with CAD," you could say something like "The objective of this meta-analysis is to investigate the relationship between serum complement C1q levels and the presence of CAD, aiming to provide insights for clinical diagnosis and treatment.
Methods:
Relevant studies on C1q and CAD were searched in PubMed, Web of Science and other literature databases. Two research team members independently cross-screened the literature according to the inclusion-exclusion criteria and assessed the literature quality. RevMan5.3 software was used for statistical analysis.
Results:
Three references were finally included, all of which had a Newcastle-Ottawa Scale (NOS) score ≥6, indicating high quality. A total of 2065 subjects were studied, including 1249 in the experimental group (CAD patients) and 816 in the control group (healthy population). Through the meta-analysis, it was found that the experimental group (CAD patients) had higher serum C1q than the control group (healthy controls) (P < .05). According to subgroup analysis, age, sex, sample size, diabetes mellitus (with/without), and serum complement C1q detection methods were not factors affecting the heterogeneity of the literature, and more data are needed for verification. Validation analysis with the fixed-effect model also showed higher C1q expression in the experimental group (P < .05). The graph of the funnel plot was basically symmetrical, suggesting low publication bias.
Conclusions:
Serum complement C1q is elevated in CAD patients, but its mechanism of action may have a dual effect, but further research is needed to understand its precise role and clinical implications.
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