Related Experiment Video
Updated: Jun 28, 2025
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
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Differences among oral carcinomas arising de novo from those associated with oral potentially malignant disorders: a
Eduardo David Piemonte1, Gerardo Marcelo Gilligan1, Federico Garola1
1Oral Medicine Department, Dentistry College, Universidad Nacional de Córdoba, Córdoba, Argentina.
Summary
Oral squamous cell carcinoma de novo (OSCC-dn) is more common and aggressive than sequential OSCC (s-OSCC). OSCC-dn presents with larger tumors, more metastases, and worse survival, necessitating targeted prevention strategies.
Area of Science:
- Oncology
- Oral Medicine
- Epidemiology
Background:
- Oral squamous cell carcinoma (OSCC) can arise de novo or sequentially after potentially malignant disorders.
- Understanding the distinct characteristics of these two pathways is crucial for effective management and prevention.
Purpose of the Study:
- To analyze the frequency of sequential oral squamous cell carcinomas (s-OSCC) versus OSCC de novo (OSCC-dn).
- To explore clinicopathologic differences between s-OSCC and OSCC-dn.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, Scopus, Cochrane, Google Scholar) up to January 2023.
- Included studies analyzed frequency, clinical, biological, demographic, biomarker, and prognostic features.
- Study quality was assessed using the Agency for Research and Health Quality tool and Newcastle-Ottawa Scale.
Main Results:
- OSCC-dn accounted for 71% of cases, while s-OSCC represented 29% (P = .00).
- s-OSCC was associated with smaller tumor size (T1/T1+T2) and fewer metastases.
- OSCC-dn showed larger tumor size, more regional/distant metastases, advanced stages, and worse survival.
Conclusions:
- s-OSCC is less frequent than anticipated.
- OSCC-dn exhibits distinct clinical, biological, and prognostic features.
- Novel prevention strategies, including urgent referral for OSCC-dn, are recommended.
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