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High-Density Polyethylene Custom Focusing Lenses for High-Resolution Transient Terahertz Biomedical Imaging Sensors.

Debamitra Chakraborty1,2, Robert Boni2, Bradley N Mills3

  • 1Materials Science Program, University of Rochester, Rochester, NY 14627-0166, USA.

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Summary

New high-density polyethylene (HDPE) lenses improve terahertz time-domain spectroscopy (THz-TDS) imaging resolution for detecting tissue malignancies. This advancement offers enhanced noninvasive biomedical imaging capabilities for improved diagnostics.

Keywords:
aspheric lenshigh-density polyethylene lens materialhigh-resolution THz imaginglens designterahertzterahertz medical imaging of tissue malignanciesterahertz-time-domain spectroscopy

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Area of Science:

  • Biomedical Optics
  • Terahertz Spectroscopy
  • Medical Imaging Technology

Background:

  • Transient terahertz time-domain spectroscopy (THz-TDS) is a promising non-ionizing imaging technique for detecting tissue malignancies.
  • Existing THz-TDS systems often face limitations in resolution and imaging performance.
  • Optimizing focusing optics is crucial for enhancing THz-TDS imaging capabilities.

Purpose of the Study:

  • To design and fabricate novel aspheric focusing lenses for THz-TDS systems.
  • To evaluate the performance of these new lenses compared to conventional hemispherical lenses.
  • To demonstrate the improved imaging resolution and diagnostic potential of the enhanced THz-TDS system.

Main Methods:

  • Designed aspheric lenses using specialized software, fabricated from high-density polyethylene (HDPE).
  • Integrated HDPE lenses into a THz-TDS system utilizing low-temperature GaAs photoconductive antennae.
  • Generated 2D images of murine pancreas tissue and quantitatively assessed resolution using the R2080 parameter.

Main Results:

  • Achieved a focal spot size of approximately 200 × 200 μm² at 1 THz with HDPE lenses.
  • HDPE lenses demonstrated superior lateral resolution (R2080) compared to traditional polytetrafluoroethylene (Teflon™) lenses.
  • Generated 2D maps of tissue refractive index and absorption coefficient with improved clarity.

Conclusions:

  • The designed HDPE aspheric lenses significantly enhance the resolution of THz-TDS biomedical imaging.
  • This lens-design approach offers a viable method for improving THz-TDS systems for malignancy detection.
  • The findings support the broader implementation of advanced optics in THz-TDS for various biomedical applications.