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Colorectal Cancer Diagnosis through Breath Test Using a Portable Breath Analyzer-Preliminary Data.

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A novel breath test using volatile organic compounds (VOCs) shows promise for non-invasive colorectal cancer (CRC) screening. This breath biopsy method achieved high accuracy in distinguishing CRC patients from healthy individuals.

Keywords:
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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • Current colorectal cancer (CRC) screening methods suffer from low reliability and patient compliance.
  • Volatile organic compounds (VOCs) in exhaled breath offer a potential non-invasive biomarker for CRC detection.

Purpose of the Study:

  • To assess the reliability of a portable micro-gas chromatograph device for rapid, on-site CRC diagnosis via breath analysis.
  • To identify VOC biomarkers for differentiating CRC patients from healthy controls (HC).

Main Methods:

  • Prospective trial involving breath sample collection from CRC patients and HC at a referral center.
  • Analysis of breath samples using an automated portable gas chromatography device.
  • Machine learning and statistical methods (LDA, PCA) to identify discriminant VOCs.

Main Results:

  • The study enrolled 68 subjects (36 CRC, 32 HC).
  • Based on three VOCs, the device achieved 87.5% specificity, 94.4% sensitivity, and 91.2% accuracy in identifying CRC patients.
  • High diagnostic performance was validated on separate training and testing sets.

Conclusions:

  • Breath biopsy using VOC analysis is a promising non-invasive tool for CRC detection.
  • The portable device enables rapid, on-site diagnosis, potentially improving screening adherence.
  • Further validation is warranted to establish breath analysis as a standard CRC screening modality.