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Updated: Jun 28, 2025
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The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
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Clinical Relevance of Physical Function Outcomes in Cancer Cachexia
Lucas Caeiro1,2, Sofia Jaramillo Quiroz1,2, Jenna S Hegarty1
1Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.
Cancers
|April 13, 2024
Summary
Defining functional impairment in cancer cachexia is crucial for treatment development. This review suggests a hand grip strength deficit of 3-6 kg may indicate clinical relevance for cancer cachexia patients.
Area of Science:
- Oncology
- Clinical Medicine
- Rehabilitation Science
Background:
- Managing cancer and treatment side effects on patient function and quality of life is vital.
- Cancer cachexia significantly reduces functional capacity, yet clear criteria for impairment are lacking.
- This gap hinders the development of effective therapies for cancer cachexia.
Purpose of the Study:
- To review evidence for clinically meaningful criteria of functional impairment in cancer patients with or without cachexia.
- To evaluate criteria for physical function changes over time in cancer cachexia interventional studies.
Main Methods:
- Literature review of cross-sectional and interventional studies.
- Focus on functional assessments, particularly hand grip strength (HGS).
Main Results:
- Hand grip strength was the most common functional assessment.
- A deficit of 3-6 kg in HGS may be clinically relevant for cancer cachexia.
- Multimodal therapies focusing on skeletal muscle may improve HGS in cachectic patients with weight loss.
Conclusions:
- Clinically relevant criteria for functional impairment in cancer cachexia are needed.
- Further research should establish cohort-specific criteria and explore patient-reported outcomes.
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