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Baseline Functional Performance Predicts Better Long-Term Self-Reported Physical Function After Auto-HSCT.

Lindsey J Anderson1,2, Lily Okamura1, Nina Dhunjishah1

  • 1Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

Journal of Clinical Medicine
|June 12, 2026
PubMed
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This summary is machine-generated.

Baseline functional performance predicts longer-term quality of life (QOL) after autologous hematopoietic stem cell transplantation (Auto-HSCT). Physical tests like the 30-second chair stand and 6-minute walk can identify patients needing supportive care post-transplant.

Area of Science:

  • Hematology
  • Transplantation immunology
  • Rehabilitation medicine

Background:

  • Identifying predictors of long-term quality of life (QOL) after autologous hematopoietic stem cell transplantation (Auto-HSCT) is crucial for targeted supportive care.
  • Baseline factors like age, weight loss, and functional performance may influence post-transplant recovery and QOL.

Purpose of the Study:

  • To determine baseline predictors of QOL up to two years following Auto-HSCT.
  • To investigate the association between baseline functional status and subsequent QOL and symptom burden.

Main Methods:

  • A cohort of 23 U.S. Veterans undergoing Auto-HSCT were assessed for physical function, body composition, and QOL before and at multiple time points up to two years post-transplant.
  • Generalized Estimating Equation regression and Spearman's correlations were used to analyze changes in QOL and the impact of baseline variables.
Keywords:
30 s chair stand test6 min walk testautologous hematopoietic stem cell transplantationmuscle functionmuscle massphysical functionquality of life

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Main Results:

  • Depression and anxiety improved post-transplant, while fatigue and vitality showed initial worsening. Bone-Marrow-Transplant-related QOL improved by 5 months.
  • Baseline performance on the 30-second chair stand and 6-minute walk tests consistently correlated with better self-reported function and lower symptom burden at 1-2 years post-HSCT.
  • Older age and weight loss at baseline predicted worse initial QOL but not longer-term outcomes.

Conclusions:

  • Baseline functional performance is a significant predictor of QOL during the two-year recovery period after Auto-HSCT.
  • The 30-second chair stand and 6-minute walk tests show promise as rehabilitation targets and predictors of QOL, fitness, and mortality post-Auto-HSCT.
  • Further larger, controlled studies are needed to validate these findings.