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Glycoprotein Matrix Zinc Exhibits Improved Absorption: A Randomized Crossover Trial.
Ralf Jäger1, Martin Purpura1, Jaci Davis2
1Increnovo LLC, Whitefish Bay, WI 53217, USA.
Nutrients
|April 13, 2024
Summary
Glycoprotein matrix-bound zinc (GPM) showed significantly higher absorption compared to zinc oxide. This enhanced bioavailability suggests GPM as a superior zinc supplement form for improved nutrient uptake.
Area of Science:
- Nutritional biochemistry
- Mineral metabolism
- Food science
Background:
- Microbial biotransformation of minerals via glycosylation creates nutrient-bound food matrices.
- This process enhances nutrient bioavailability, particularly for minerals like zinc.
- Glycoprotein matrix-bound zinc (GPM) is a novel form of mineral supplementation.
Purpose of the Study:
- To compare the absorption of glycoprotein matrix-bound zinc (GPM) against inorganic zinc oxide.
- To evaluate the pharmacokinetic differences between GPM zinc and zinc oxide in human participants.
Main Methods:
- Sixteen participants ingested 11 mg of zinc from either GPM or zinc oxide.
- Blood samples were collected at multiple time points up to 480 minutes post-ingestion.
- Zinc concentrations in blood were analyzed to determine absorption rates.
Main Results:
- GPM zinc concentrations were significantly higher at 120, 180, and 240 minutes post-ingestion compared to zinc oxide.
- GPM significantly increased the integrated area under the curve (iAUC) by 40%.
- Cmax values for GPM were 10% higher, though Tmax did not reach statistical significance.
Conclusions:
- Zinc bound to a glycoprotein matrix demonstrates significantly increased absorption compared to zinc oxide.
- GPM represents a more bioavailable form of zinc supplementation.
- Further research may explore the long-term benefits of GPM for zinc status.
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