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Published on: June 21, 2018
Blood Phytosterol Concentration and Genetic Variant Associations in a Sample Population.
Leticia Garrido-Sanchez1, Elisabet Leiva-Badosa1, Josep Llop-Talaveron1
1Pharmacy Department, Hospital Universitari Bellvitge, IDIBELL, Universitat Barcelona, 08907 L'Hospitalet de Llobregat, Spain.
This study investigated plasma phytosterols (PS) and their relation to specific genetic variants (SNVs). Certain SNVs may help prevent elevated PS levels and potential liver conditions.
Area of Science:
- Biochemistry
- Genetics
- Clinical Medicine
Background:
- Plasma phytosterol levels are influenced by various factors.
- Understanding genetic predispositions is crucial for managing phytosterol-related health risks.
Purpose of the Study:
- To determine plasma phytosterol (PS) levels and analyze single nucleotide variants (SNVs) in ABCG8 and ABO loci.
- To investigate the association between these SNVs and plasma PS concentrations.
- To identify variables associated with plasma PS levels in adults.
Main Methods:
- Collected dietary habits, biochemical parameters, SNVs, and biometric/demographic data.
- Analyzed plasma concentrations of campesterol, sitosterol, sitostanol, lanosterol, and stigmasterol.
- Utilized a generalized linear model to assess associations.
Main Results:
- Cholesterol and age positively correlated with total PS; BMI showed a negative association.
- rs4245791 (ABCG8) homozygous T allele linked to lower campesterol.
- rs657152 (ABO) GG alleles associated with the lowest campesterol levels.
Conclusions:
- Screening specific SNVs may aid in preventing elevated plasma PS and potential phytosterols-associated liver disease (PNALD).
- Further research is required to fully elucidate the determinants of plasma phytosterol concentrations.
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