Cell-mediated nanoparticle delivery systems: towards precision nanomedicine

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Drug Delivery Systems

Background:

• Traditional nanoparticle delivery faces challenges in circulation time and targeted delivery.
• Cell-mediated nanoparticle delivery systems (CMNDDs) offer a novel approach by utilizing cells as natural carriers.
• CMNDDs exploit inherent cell characteristics like homing, prolonged circulation, and barrier penetration.

Purpose of the Study:

• To review recent advancements in the fabrication of cell-mediated nanoparticle delivery systems.
• To highlight the diverse biomedical applications of CMNDDs in disease treatment.
• To discuss current challenges and future perspectives in the field of CMNDDs.

Main Methods:

• In vitro construction of CMNDDs using ligand-receptor interactions, non-covalent, and covalent interactions.
• In vivo construction of CMNDDs through nanoparticle internalization or attachment to cells like macrophages, red blood cells, and platelets.
• Review of literature on CMNDD fabrication techniques and their application in various disease models.

Main Results:

• CMNDDs demonstrate enhanced blood circulation times and the ability to cross biological barriers, including the blood-brain barrier.
• Successful application of CMNDDs in preclinical models for treating cancer, central nervous system disorders, lung diseases, and cardiovascular diseases.
• Various cell types, including macrophages, red blood cells, and neutrophils, can be effectively utilized as carriers for nanoparticles.

Conclusions:

• Cell-mediated nanoparticle delivery systems represent a promising strategy for precision targeting and enhanced therapeutic efficacy.
• Further research into fabrication methods and clinical translation is crucial for realizing the full potential of CMNDDs.
• CMNDDs offer a versatile platform for developing advanced drug delivery solutions across a spectrum of diseases.