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Non-O Blood Group Is Associated with High Thrombus Burden and Poor Short- and Long-Term Prognosis in ST-Segment

Kenan Toprak1, Mustafa Kaplangöray2, Muhammed Bahadır Omar3

  • 1Department of Cardiology, Faculty of Medicine, Harran University, Sanliurfa, Turkey.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|April 14, 2024
PubMed

Insights

Non-O blood groups are linked to higher thrombus burden and increased mortality in ST-segment elevation myocardial infarction (STEMI) patients. This finding highlights blood type as a factor influencing STEMI prognosis and outcomes.

Area of Science:

  • Cardiology
  • Hematology
  • Genetics

Background:

  • The ABO blood group system is a key factor in hemostasis and thrombosis.
  • Understanding its role in ST-segment elevation myocardial infarction (STEMI) is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the association between non-O blood groups and thrombus burden (TB) in STEMI patients.
  • To evaluate the prognostic implications of non-O blood groups on short-term and long-term clinical outcomes in STEMI.

Main Methods:

  • Retrospective analysis of 1,180 STEMI patients undergoing primary percutaneous coronary intervention.
  • Patients were categorized by thrombus burden and ABO blood group.
  • Clinical characteristics, laboratory parameters, and short-term (30-day) and long-term (12-month) outcomes were assessed.

Main Results:

  • Non-O blood groups were significantly associated with increased thrombus burden in STEMI patients (p = 0.001).
  • Non-O blood group was an independent predictor of high thrombus burden (OR: 1.726, p < 0.001).
  • Patients with non-O blood groups exhibited higher short-term (HR: 2.480, p = 0.003) and long-term mortality (HR: 2.347, p = 0.001).

Conclusions:

  • The ABO blood group system plays a significant role in STEMI outcomes.
  • Non-O blood groups are associated with greater thrombus burden and poorer prognosis in STEMI.
  • Personalized treatment strategies considering blood group status may improve reperfusion and outcomes in STEMI patients, warranting further investigation.
Abstract

Keywords:
ABO blood groupST-segment elevation myocardial infarctionThrombus burden

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