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Potential Effects on Elderly People From Nirsevimab Use in Infants.

Iván Sanz-Muñoz^1,2,3, Javier Castrodeza-Sanz^1,4,5, José M Eiros^1,6,7,8

¹National Influenza Centre, Valladolid, Spain.

Open Respiratory Archives

|April 15, 2024

Summary

Nirsevimab offers potential protection against respiratory syncytial virus (RSV) for infants. However, its indirect benefit to the elderly is limited, making direct immunization a priority for older adults.

Keywords:

Elderly Nirsevimab Respiratory syncytial virus Vaccines

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Published on: July 31, 2021

Area of Science:

Immunology
Virology
Public Health

Background:

Respiratory syncytial virus (RSV) poses a significant threat to vulnerable populations, including infants and the elderly.
Nirsevimab, a monoclonal antibody, has shown promise in infant RSV prophylaxis.
The potential for indirect protection of the elderly through infant Nirsevimab administration warrants investigation.

Purpose of the Study:

To evaluate the potential indirect protective benefits of infant Nirsevimab therapy on the elderly population against RSV.
To assess the limitations and significance of this indirect protection in the context of overall RSV transmission dynamics.

Main Methods:

Review of existing studies on Nirsevimab's efficacy in reducing viral load in infants.
Analysis of RSV transmission patterns in the elderly, considering common sources of infection.
Consideration of RSV persistence in human reservoirs and year-round transmission.

Main Results:

Nirsevimab's long half-life can reduce viral load in infants, potentially limiting RSV spread.
RSV transmission among the elderly primarily occurs between peers or from school-aged children, not solely from infants.
Year-round RSV circulation and human reservoirs diminish the sustained protective effect of infant-targeted Nirsevimab for the elderly.

Conclusions:

While infant Nirsevimab may offer some limited, indirect protection to the elderly, it is not a primary strategy.
The protective benefits for the elderly are likely to be testimonial rather than substantial.
Prioritizing the immunization of the elderly with licensed and developing RSV vaccines is crucial for effective disease prevention.