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Updated: May 3, 2026
Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
Published on: July 23, 2016
Immunogenicity and Potential for Intraocular Inflammation of Intravitreal Anti-VEGF Drugs
Hyeong Min Kim1,2, Se Joon Woo1
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea.
Background:
Concerns of intraocular inflammation associated with intravitreal administration of anti-VEGF drugs have been risen and the exact mechanism is not yet elucidated.
Objective:
To explore the relationship between immunogenicity and intraocular inflammation in intravitreal anti-VEGF drugs.
Methods:
This review examines the immunogenicity of individual intravitreal anti-VEGF drugs and their potential link to intraocular inflammation.
Results:
We suggest that the main cause of intraocular inflammation is the presence of pre-existing and treatment-induced antidrug antibodies, along with considerations related to the molecular structure, which includes the drug's format and size.
Conclusions:
Researchers and clinicians involved in the advancement of new anti-VEGF drugs should take into consideration the factors related to intraocular inflammation that have been discussed.
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