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Updated: Jun 28, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Copper-catalyzed ortho-thiocyanation of aromatic amines
Monak Patel1, Nitish Kumar2, Hussain Bhukya2
1Department of Chemistry, Sardar Vallabhbhai National Institute of Technology Surat, Gujarat - 395 007, India. togatinaveen123@gmail.com.
Abstract:
A copper-catalyzed direct ortho-Csp2-H thiocyanation of free anilines has been developed. This method employs stable and non-toxic ammonium thiocyanate as a thiocyanation source, and tert-butyl hydroperoxide as the oxidant, enabling the synthesis of ortho-thiocyanated anilines with good yields and broad substrate tolerance. Hitherto, no reports have been found in the literature for the ortho-thiocyanation of aromatic amines, making this reaction an important breakthrough in synthetic organic chemistry.
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