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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow
Xin-Jie Lin1, Chien-Lung Wang2, Chi-How Peng2
1Department of Applied Chemistry, National Yang Ming Chiao Tung University, No. 1001 University Road, Hsinchu, 30010, Taiwan.
Abstract:
Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.
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