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HMPA-Enabled Direct γ'-Arylation of Cyclic Vinylogous Esters

Yan-Xun Li1, Wei-Ting Zhao1, Yen-Ku Wu1,2

  • 1Department of Applied Chemistry and Center for Emergent Functional Matter Science, National Yang Ming Chiao Tung University, 1001 University Road, Hsinchu City 30010, Taiwan.

Organic Letters
|February 5, 2026
PubMed
Summary

Researchers developed a palladium-catalyzed method for regioselective arylation of cyclic vinylogous esters. This approach overcomes challenges in controlling regioselectivity for conjugated carbonyl systems, enabling new synthetic pathways.

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