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Updated: Jun 28, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
Sedation, narcotic and neuromuscular blockade in mechanically ventilated patients with COVID-19
Ghazi Rizvi1, David Yamane1, Danielle Davison1
1Department of Anesthesiology and Critical Care, George Washington University Hospital, Located at, 900 23rd Street, NW, Washington DC, 20037, USA.
Objective:
To describe the sedation, narcotic and neuromuscular blockade usage in ventilated patients with COVID-19 pneumonia.
Design:
Single-Center Retrospective Review.
Setting:
George Washington University Hospital in Washington, D.C.
Patients:
62 patients with COVID-19 respiratory failure requiring mechanical ventilation admitted from March 2020 to June 2020.
Intervention:
None.
Measurements And Main Results:
Patients with COVID-19 respiratory failure required multiple sedative/narcotic infusions to achieve sedation requirements and at doses that were significantly more when compared to a general medical-surgical ICU population (represented by the MIND-USA cohort). The most common infusions were Dexmedetomadine and Propofol. Approximately 17% of our patients required a neuromuscular blockade infusion as well. Prior to intubation, narcotic utilization was stable and low.
Conclusion:
Patients with COVID-19 respiratory failure requiring mechanical ventilation have higher sedation and narcotic requirements than general ICU patients.
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