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Amphetamine response in borderline patients.

S C Schulz, P M Schulz, C Dommisse

    Psychiatry Research
    |June 1, 1985
    PubMed
    Summary
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    d-amphetamine induced psychosis in 50% of borderline patients, unlike normal subjects. Borderline patients showed altered well-being and growth hormone responses, suggesting distinct pharmacodynamics.

    Area of Science:

    • Psychiatry
    • Pharmacology
    • Neuroscience

    Background:

    • d-amphetamine responses are well-documented in schizophrenia, depression, and bipolar disorder.
    • Borderline personality disorder (BPD) shares theoretical links with these conditions.
    • Investigating amphetamine's effects in BPD may elucidate underlying neurobiological mechanisms.

    Purpose of the Study:

    • To compare the behavioral and biological effects of d-amphetamine in borderline personality disorder patients versus normal subjects.
    • To determine if borderline patients exhibit unique pharmacodynamic responses to amphetamine.

    Main Methods:

    • Eight borderline patients and a control group of normal subjects received 30 mg of d-amphetamine orally in a double-blind, placebo-controlled study.
    • Psychotic symptoms, global well-being, and growth hormone levels were assessed.

    Related Experiment Videos

  • Patient responses were correlated with scores on the Diagnostic Interview for Borderlines.

    • Main Results:

    • Amphetamine induced psychotic symptoms in 50% of borderline patients, with no psychotic reactions in normal subjects.
    • Borderline patients reported significantly higher global well-being compared to controls.
    • A significant inverse correlation was observed between global response and Diagnostic Interview for Borderlines scores.
    • Borderline patients showed a trend towards decreased growth hormone response to amphetamine.

    Conclusions:

    • Borderline personality disorder patients exhibit distinct pharmacodynamic responses to d-amphetamine compared to normal individuals.
    • Amphetamine can unmask or induce psychosis in a significant portion of the borderline patient population.
    • These findings support the separation of borderline patients from normal subjects based on their pharmacological profiles.